C5aR antagonist inhibits LPS-induced inflammation in human gingival fibroblasts via NF-κB and MAPK signaling pathways.

Yan ChenYang LiuHao LiRisu HunaXiaohan TanNing LiYiying ZhangXiaohui Jiao Ming-Yue Liu

Published in: Journal of applied oral science : revista FOB (2023)

These findings suggested that C5aRA attenuated the release of inflammatory cytokines in LPS-induced HGFs by blocking the activation of the NF-κB and MAPK signaling pathways.

Keyphrases

lps induced
signaling pathway
pi k akt
inflammatory response
oxidative stress
endothelial cells
induced apoptosis
epithelial mesenchymal transition
induced pluripotent stem cells
pluripotent stem cells