Nonsteroidal Anti-Inflammatory Drugs and Their Neuroprotective Role After an Acute Spinal Cord Injury: A Systematic Review of Animal Models.
Mark J LambrechtsJames L CookPublished in: Global spine journal (2020)
NSAIDs' effectiveness after SCI is largely determined by its ability to inhibit Rho-A. NSAIDs are a promising therapeutic option in acute SCI patients because they appear to decrease cord edema and inflammation, increase axonal sprouting, and improve motor function with minimal side effects. Studies are limited by heterogeneity, small sample size, and the use of animal models, which might not replicate the therapeutic effects in humans. There are no published human studies evaluating the safety and efficacy of these drugs after a traumatic cord injury. There is a need for well-designed prospective studies evaluating ibuprofen or indomethacin after adult spinal cord injuries.
Keyphrases
- spinal cord injury
- spinal cord
- anti inflammatory drugs
- neuropathic pain
- liver failure
- end stage renal disease
- case control
- respiratory failure
- drug induced
- endothelial cells
- ejection fraction
- chronic kidney disease
- randomized controlled trial
- systematic review
- peritoneal dialysis
- oxidative stress
- aortic dissection
- hepatitis b virus
- single cell
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- induced pluripotent stem cells
- meta analyses