Microarray Analysis of Long Non-Coding RNAs in Lung Tissues of Patients with COPD and HOXA-AS2 Promotes HPMECs Proliferation via Notch1.

Ai-Yuan ZhouYi-Yang ZhaoZi-Jing ZhouJia-Xi DuanYi-Zhang ZhuShan CaiPing Chen

Published in: International journal of chronic obstructive pulmonary disease (2020)

Our results demonstrated that differentially expressed lncRNAs may act as potential molecular biomarkers for the diagnosis of COPD, and HOXA-AS2 was involved in the pathogenesis of COPD by regulating HPMECs proliferation via Notch1, which may provide a new approach for COPD treatment.

Keyphrases

long non coding rna
chronic obstructive pulmonary disease
lung function
poor prognosis
signaling pathway
cell proliferation
gene expression
long noncoding rna
climate change