Takayasu arteritis: A distinct syndrome of large vessel vasculitis: A view point by late Professor Paul Bacon.
Shubhini A SarafPublished in: International journal of rheumatic diseases (2019)
Takayasu arteritis (TA), despite being classified as a large vessel vasculitis, has distinct genetic, pathological and clinical features as compared to giant cell arteritis. It is a rare disease seen more commonly in Asian countries. The challenge lies in assessing the degree of inflammation in a narrowed vessel and immunosuppressive therapy improves inflammatory features but is unable to open up an occluded vessel. It may have a positive effect on retarding further occlusion. Like antineutrophil cytoplasmic antibody-associated vasculitis, TA needs a collaborative effort to do randomized controlled therapy to provide benefit to patients.
Keyphrases
- giant cell
- end stage renal disease
- oxidative stress
- ejection fraction
- newly diagnosed
- chronic kidney disease
- double blind
- prognostic factors
- minimally invasive
- genome wide
- randomized controlled trial
- stem cells
- quality improvement
- case report
- dna methylation
- copy number
- patient reported outcomes
- study protocol
- bone marrow