Clinical profile of fatal familial insomnia: phenotypic variation in 129 polymorphisms and geographical regions.

Jing ZhangMin ChuZiChen TianKeXin XieYue CuiLi LiuJiaLi MengHaiHan YanYang-Mingyue JiZhuyi JiangTian-Xinyu XiaDongxin WangXin WangYe ZhaoHong YeJunjie LiLin WangLiyong Wu

Published in: Journal of neurology, neurosurgery, and psychiatry (2021)

Insomnia, RPD and hypertension are representative key clinical presentations of FFI. Phenotypic variations in genotypes and geographic regions were documented. Prion protein gene 129 Met was considered to be a risk factor for FFI in the non-Asian population, and 129 polymorphisms could modify survival duration.

Keyphrases

blood pressure
genome wide
tyrosine kinase
cross sectional
dna methylation
amino acid
physical activity
transcription factor