HPV-16 E2/E6 and POU5F1B as Biomarkers to Determine Cervical High-Grade Squamous Lesions and More.

Lihua Chen Binhua DongHangjing GaoHuifeng XueDiling PanPeng-Ming Sun

Published in: Journal of inflammation research (2020)

HPV-16-E2/E6≤0.6471 or POU5F1B≥1.0310 in cervical exfoliated cells can be used as a reliable predictor of CIN2+. POU5F1B can be used as a new auxiliary biomarker to determine the HPV infection status and a reliable predictor of CIN2+. The expression of POU5F1B≥1.0310 had the highest OR for the detection of CIN2+.

Keyphrases

high grade
low grade
induced apoptosis
poor prognosis
endoplasmic reticulum stress
binding protein
signaling pathway
oxidative stress
long non coding rna