Comparative risk of anemia and related micronutrient deficiencies after Roux-en-Y gastric bypass and sleeve gastrectomy in patients with obesity: An updated meta-analysis of randomized controlled trials.
Yeongkeun KwonJane HaYong-Hoon LeeDohyang KimChang Min LeeJong-Han KimSungsoo ParkPublished in: Obesity reviews : an official journal of the International Association for the Study of Obesity (2022)
Although Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are the most prevalent bariatric surgical procedures, high-level evidence is scarce regarding the assessment of postoperative nutritional risk in RYGB versus SG. Therefore, we performed a systematic review and meta-analysis to compare the risk of anemia and related micronutrient deficiencies after RYGB and SG. We analyzed 10 randomized controlled trials that compared RYGB and SG with reported incidence of postoperative anemia and/or anemia-related micronutrient deficiencies (iron, vitamin B 12 , or folate). There were no significant differences in the risk of postoperative anemia (moderate level of evidence), iron deficiency (high level of evidence), or folate deficiency (moderate level of evidence). Patients undergoing RYGB had a higher risk of postoperative vitamin B 12 deficiency than those undergoing SG (relative risk, 1.86; 95% confidence interval, 1.15-3.02; p = 0.012; high level of evidence). Our findings imply that patients undergoing RYGB require more stringent vitamin B 12 supplementation and surveillance than those undergoing SG. Additionally, our results may aid patients with high concern for anemia and related micronutrient deficiencies in making informed decisions regarding surgical methods based on nutritional risk.
Keyphrases
- roux en y gastric bypass
- iron deficiency
- patients undergoing
- weight loss
- gastric bypass
- obese patients
- bariatric surgery
- chronic kidney disease
- randomized controlled trial
- type diabetes
- metabolic syndrome
- public health
- body mass index
- clinical trial
- weight gain
- insulin resistance
- adipose tissue
- physical activity
- replacement therapy
- meta analyses