Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
null nullnull nullnull nullPatrick R LawlerEwan C GoligherJeffrey S BergerMatthew D NealBryan J McVerryJose C NicolauMichelle N GongMarc CarrierRobert S RosensonHarmony R ReynoldsAlexis F TurgeonJorge EscobedoDavid T HuangCharlotte Ann BradburyBrett L HoustonLucy Z KornblithAnand KumarSusan R KahnMary CushmanZoe McQuiltenArthur S SlutskyKeri S KimAnthony C GordonBridget-Anne KirwanMaria M BrooksAlisa M HigginsRoger J LewisElizabeth LorenziScott M BerryLindsay R BerryAaron W AdayFarah Al-BeidhDjillali AnnaneYaseen M ArabiDiptesh AryalLisa Baumann KreuzigerAbigail BeaneZahra BhimaniShailesh BihariHenny H BillettLindsay BondMarc BontenFrank BrunkhorstMeredith BuxtonAdrian BuzgauLana A CastellucciSweta ChekuriJen-Ting ChenAllen C ChengTamta ChkhikvadzeBenjamin CoiffardTodd W CostantiniSophie de BrouwerLennie P G DerdeMichelle A DetryAbhijit DuggalVladimír DžavíkMark B EffronLise J EstcourtBrendan M EverettDean A FergussonMark FitzgeraldRobert A FowlerJean P GalanaudBenjamin T GalenSheetal GandotraSebastian García-MadronaTimothy D GirardLucas Colombo GodoyAndrew L GoodmanHerman GoossensCameron GreenYonatan Y GreensteinPeter L GrossNaomi M HamburgRashan HaniffaGeorge HannaNicholas HannaSheila M HegdeCarolyn M HendricksonR Duncan HiteAlexander A HindenburgAluko A HopeJames M HorowitzChristopher M HorvatKristin HudockBeverley J HuntMansoor HusainRobert C HyzyVivek N IyerJeffrey R JacobsonDevachandran JayakumarNorma M KellerAkram KhanYuri KimAndrei L KindzelskiAndrew J KingM Margaret KnudsonAaron E KornblithVidya KrishnanMatthew E KutcherMichael A LaffanFrancois LamontagneGrégoire Le GalChristine M LeeperEric S LeiferGeorge LimFelipe Gallego LimaKelsey LinstrumEdward LittonJose Lopez-SendonJosé Luis López-Sendon MorenoSylvain A LotherSaurabh MalhotraMiguel MarcosAndréa Saud MarinezJohn C MarshallNicole MartenMichael A MatthayDaniel F McAuleyEmily G McDonaldAnna McGlothlinShay P McGuinnessSaskia MiddeldorpStephanie K MontgomerySteven C MooreRaquel Morillo GuerreroPaul R MounceySrinivas MurthyGirish B NairRahul NairAlistair D NicholBrenda Nunez-GarciaAmbarish PandeyPauline K ParkRachael L ParkeJane C ParkerSam ParniaJonathan D PaulYessica S Pérez GonzálezMauricio PompilioMatthew E PrekkerJohn G QuigleyNatalia S RostKathryn RowanFernanda O SantosMarlene SantosMayler Olombrada SantosLewis SatterwhiteChristina T SaundersRoger E G SchutgensChristopher W SeymourDeborah M SiegalDelcio G SilvaManu Shankar-HariJohn P SheehanAneesh B SinghalDayna SolvasonSimon J StanworthTobias TritschlerAnne M TurnerWilma van Bentum-PuijkFrank L van de VeerdonkSean van DiepenGloria Vazquez-GrandeLana WahidVanessa WarehamBryan J WellsR Jay WidmerJennifer G WilsonEugene YuriditskyFernando Godinho ZampieriDerek C AngusColin J McArthurSteven A WebbMichael E FarkouhJudith S HochmanRyan ZarychanskiPublished in: The New England journal of medicine (2021)
In noncritically ill patients with Covid-19, an initial strategy of therapeutic-dose anticoagulation with heparin increased the probability of survival to hospital discharge with reduced use of cardiovascular or respiratory organ support as compared with usual-care thromboprophylaxis. (ATTACC, ACTIV-4a, and REMAP-CAP ClinicalTrials.gov numbers, NCT04372589, NCT04505774, NCT04359277, and NCT02735707.).