Efficacy and safety of controlled-release oxycodone/naloxone versus controlled-release oxycodone in Korean patients with cancer-related pain: a randomized controlled trial.

Kyung-Hee LeeTae Won KimJung-Hun KangJin-Soo KimJin-Seok AhnSun-Young KimHwan-Jung YunYoung-Jun EumSung Ae KohMin Kyoung KimYong Sang HongJeong Eun KimGyeong-Won Lee

Published in: Chinese journal of cancer (2017)

OXN-CR was non-inferior to OX-CR in terms of pain reduction after 4 weeks of treatment and had a similar safety profile. Studies in larger populations of Korean patients with cancer-related pain are needed to further investigate the effectiveness of OXN-CR for long-term pain control and constipation alleviation. Trial registration ClinicalTrials.gov NCT01313780, registered March 8, 2011.

Keyphrases

chronic pain
pain management
neuropathic pain
randomized controlled trial
systematic review
spinal cord
study protocol
spinal cord injury
phase iii
phase ii
open label
replacement therapy