Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water.

Nnamdi Akporji Vani Singhania Jade Dussart-Gautheret Fabrice Gallou Bruce H Lipshutz

Published in: Chemical communications (Cambridge, England) (2021)

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M. Transformations are provided that illustrate the variety of sequences now possible in 1-pot as representative examples of this environmentally attractive approach to organic synthesis.

Keyphrases

photodynamic therapy
cancer therapy
locally advanced
combination therapy
room temperature
cross sectional
genetic diversity