Cycloartane-type triterpenoids from the whole plants of Macrosolen bidoupensis.
Kieu Hung LeBui Linh Chi HuynhNguyen Kim Tuyen PhamThi Hong Tuoi DoLe Thanh Tuyen NguyenVan Son DangQuoc Luan NgoThi Ngoc Mai TranTrong Dat BuiNhat Minh PhanDinh Tri MaiNguyen Kim Tuyen PhamPublished in: Journal of Asian natural products research (2021)
One new cycloartane-type triterpenoid, named macrobidoupoic acid A (as an C-24 epimeric mixture, 4a, 4 b), together with three known ones (1-3), were clarified by different chromatography from the M. bidoupensis whole plants. Triterpenoids (1, 3 & 4) were detected for the first time from the Macrosolen genus. Chemical structures of them were illuminated using HR-ESI-MS, and NMR (1 D & 2 D) assessments. The cytotoxic properties of triterpenoids (3 & 4) were examined against two human cancer cell lines (A549, and RD) by MTT assay. As results shown, triterpenoids (3 & 4) possessed moderate cytotoxic activity against A549 and RD cancer cells (IC50 ranged from 5.44 to 39.52 μM).