Immunohistochemical Expression of Caspase1 and Epidermal Growth Factor Receptor in Invasive Breast Carcinoma and Their Biological and Prognostic Associations.
Eman Tawfik EnanAmal Abd El-HafezEmadeldeen HussinHeba Salah El Din Ismail HanyPublished in: Asian Pacific journal of cancer prevention : APJCP (2024)
Caspase1 was positive in 54.2% of breast carcinomas and its positivity was significantly associated with smaller tumor size, absence of metastasis/recurrence, luminal A and B molecular subtypes and longer OS (p<0.05). EGFR overexpression was detected in 32.7% of carcinomas and was significantly associated with larger tumor size, TNBLBC and a shorter OS (p<0.05). Caspase1-negative/EGFR-overexpression pattern comprised 14.4% of carcinomas and had the worst prognostic associations including larger tumor size, metastasis/recurrence, TNBLBC subtype and shortest OS (p=0.002, 0.002, 0.004 and ≤0.001 respectively). Conclusions: Combined Caspase1/EGFR IHC expression may provide a tool for selection of patients who benefit from combined EGFR-inhibitors with miR-155-5p down-regulators or photodynamic therapy via induction of apoptosis/pyroptosis in EGFR-overexpression carcinomas through enhanced Caspase1 signaling.
Keyphrases
- epidermal growth factor receptor
- cell death
- tyrosine kinase
- advanced non small cell lung cancer
- small cell lung cancer
- induced apoptosis
- high grade
- photodynamic therapy
- poor prognosis
- transcription factor
- cell proliferation
- endoplasmic reticulum stress
- cell cycle arrest
- oxidative stress
- binding protein
- signaling pathway
- long non coding rna
- single molecule
- pi k akt