Cell Adhesion Molecules are Upregulated and May Drive Inflammation in Chronic Rhinosinusitis with Nasal Polyposis.

Brennan J BlightAmarbir S GillJorgen S SumsionChelsea E PollardShaelene AshbyGretchen M OakleyJeremiah A AltAbigail Pulsipher

Published in: Journal of asthma and allergy (2021)

The systemic and local expression of ITGAM, ITGB2, and ICAM-3 is significantly upregulated in CRSwNP, suggesting that integrin complex ITGAM/ITGB2 and ICAM-3 serve a potential role in inflammation-mediated signaling in CRSwNP.

Keyphrases

chronic rhinosinusitis
cell adhesion
oxidative stress
poor prognosis
binding protein
drug induced