Gene/drug-embedded nanoscale metal azolate framework-7 for the reversal of P-glycoprotein-mediated multidrug resistance.
Xiangli LiYiming HeLin YangZhimei HeJun-Jie ZhuPublished in: Chemical communications (Cambridge, England) (2021)
We report the straightforward synthesis of ATP-responsive nanoscale metal azolate framework-7 (MAF-7) for gene/drug codelivery. The MAF-7 functions as (i) the armour to preserve DNAzymes, (ii) an ATP scavenger to lower the intracellular ATP level, and (iii) a built-in Zn2+ arsenal to initiate the biocatalysis of DNAzymes, ultimately inhibiting P-gp expression to enhance chemotherapy.
Keyphrases
- copy number
- genome wide
- atomic force microscopy
- poor prognosis
- genome wide identification
- adverse drug
- signaling pathway
- heavy metals
- emergency department
- radiation therapy
- dna methylation
- drug induced
- locally advanced
- gene expression
- transcription factor
- drug delivery
- high speed
- single molecule
- mass spectrometry
- transition metal