COVID-19 Convalescent Plasma Outpatient Therapy to Prevent Outpatient Hospitalization: A Meta-analysis of Individual Participant Data From Five Randomized Trials.

Adam C LevineYuriko FukutaMoises A HuamanJiangda OuBarry R MeisenbergBela PatelJames H PaxtonDaniel F HanleyBart Ja RijndersArvind GharbharanCasper RokxJaap Jan ZwagingaAndrea AlemanyOriol MitjàDan OuchiPere Millat-MartinezValerie Durkalski-MauldinFrederick K KorleyLarry J DumontClifton W CallawayRomina LibsterGonzalo Perez MarcDiego WappnerIgnacio EstebanFernando PolackDavid J Sullivan

Published in: medRxiv : the preprint server for health sciences (2022)

While the outpatient COVID-19 randomized controlled trial meta-analysis indicated heterogeneity in participant risk factors and convalescent plasma, the combined CCP efficacy for reducing hospitalization was significant, improving with transfusion within 5 days of symptom onset and high antibody neutralization levels.

Keyphrases

coronavirus disease
sars cov
randomized controlled trial
risk factors
systematic review
study protocol
respiratory syndrome coronavirus
single cell
machine learning
patient reported
sickle cell disease
deep learning
case control
replacement therapy