TMBur: a distributable tumor mutation burden approach for whole genome sequencing.
Emma TitmussRichard D CorbettScott DavidsonSanna AbbasiLaura M WilliamsonErin D PleasanceAdam ShlienDaniel J RenoufSteven J M JonesJanessa LaskinMarco A MarraPublished in: BMC medical genomics (2022)
TMBur, a shareable workflow, generates consistent whole genome derived TMB estimates predictive of response to ICIs across multiple analysis centres. Reproducible TMB estimates from this approach can improve collaboration and ensure equitable treatment and clinical trial access spanning jurisdictions.