Differences and Similarities in the Pattern of Early Metabolic and Morphologic Response after Induction Chemo-Immunotherapy versus Induction Chemotherapy Alone in Locally Advanced Squamous Cell Head and Neck Cancer.
Michael BeckSabine SemrauMarlen HaderleinAntoniu-Oreste GostianJulius HartwichSarina Katrin MüllerAnnett KalliesCarol-Immanuel GeppertMiriam SchonathFlorian PutzUdo S GaiplBenjamin FreyMarc SaakeHeinrich IroMichael UderArndt HartmannTorsten KuwertRainer FietkauMarkus EcksteinMarkus HechtPublished in: Cancers (2022)
Background: In head and neck cancer patients, parameters of metabolic and morphologic response of the tumor to single-cycle induction chemotherapy (IC) with docetaxel, cis- or carboplatin are used to decide the further course of treatment. This study investigated the effect of adding a double immune checkpoint blockade (DICB) of tremelimumab and durvalumab to IC on imaging parameters and their significance with regard to tumor cell remission. Methods: Response variables of 53 patients treated with IC+DICB (ICIT) were compared with those of 104 who received IC alone. Three weeks after one cycle, pathologic and, in some cases, clinical and endoscopic primary tumor responses were evaluated and correlated with a change in 18F-FDG PET and CT/MRI-based maximum-standardized uptake values (SUV max ) before (SUV max pre), after treatment (SUV max post) and residually (resSUV max in % of SUV max pre), and in maximum tumor diameter (D max ) before (D max pre) and after treatment (D max post) and residually (resD). Results: Reduction of SUV max and D max occurred in both groups; values were SUV max pre: 14.4, SUV max post: 6.6, D max pre: 30 mm and D max post: 23 mm for ICIT versus SUV max pre: 16.5, SUV max post: 6.4, D max pre: 21 mm, and D max post: 16 mm for IC alone (all p < 0.05). ResSUV max was the best predictor of complete response (IC: AUC: 0.77; ICIT: AUC: 0.76). Metabolic responders with resSUV max ≤ 40% tended to have a higher rate of CR to ICIT (88%; n = 15/17) than to IC (65%; n = 30/46; p = 0.11). Of the metabolic nonresponders (resSUV max > 80%), 33% (n = 5/15) achieved a clinical CR to ICIT versus 6% (n = 1/15) to IC ( p = 0.01). Conclusions: ICIT and IC quickly induce a response and 18F-FDG PET is the more accurate modality for identifying complete remission. The rate of discrepant response, i.e., pCR with metabolic nonresponse after ICIT was >30%.
Keyphrases
- locally advanced
- squamous cell carcinoma
- computed tomography
- radiation therapy
- high resolution
- randomized controlled trial
- magnetic resonance imaging
- stem cells
- photodynamic therapy
- systemic lupus erythematosus
- mesenchymal stem cells
- open label
- chronic kidney disease
- ejection fraction
- lymph node
- contrast enhanced
- peritoneal dialysis
- phase ii study
- ulcerative colitis
- double blind
- phase iii