Effect of MAOA DNA methylation on human in vivo protein expression measured by [ 11C]harmine positron emission tomography.
Patricia A HandschuhMatej MurgašChrysoula VrakaLukas NicsAnnette M HartmannEdda Winkler-PjrekPia Baldinger-MelichWolfgang WadsakDietmar WinklerMarcus HackerDan RujescuKatharina DomschkeRupert LanzenbergerMarie SpiesPublished in: The international journal of neuropsychopharmacology (2022)
In contrast to a previous study demonstrating an effect of methylation of a MAOA promoter region located further 5' on brain MAO-A, MAOA methylation of the region assessed here appears to affect brain protein levels to a limited extent at most. The observed effect of season on methylation levels is in accordance with extensive evidence for seasonal effects within the serotonergic system.
Keyphrases
- dna methylation
- positron emission tomography
- genome wide
- computed tomography
- gene expression
- resting state
- white matter
- endothelial cells
- magnetic resonance
- functional connectivity
- pet ct
- pet imaging
- cerebral ischemia
- copy number
- multiple sclerosis
- transcription factor
- pluripotent stem cells
- blood brain barrier
- small molecule