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Effect of MAOA DNA methylation on human in vivo protein expression measured by [ 11C]harmine positron emission tomography.

Patricia A HandschuhMatej MurgašChrysoula VrakaLukas NicsAnnette M HartmannEdda Winkler-PjrekPia Baldinger-MelichWolfgang WadsakDietmar WinklerMarcus HackerDan RujescuKatharina DomschkeRupert LanzenbergerMarie Spies
Published in: The international journal of neuropsychopharmacology (2022)
In contrast to a previous study demonstrating an effect of methylation of a MAOA promoter region located further 5' on brain MAO-A, MAOA methylation of the region assessed here appears to affect brain protein levels to a limited extent at most. The observed effect of season on methylation levels is in accordance with extensive evidence for seasonal effects within the serotonergic system.
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