Polymorphic variants of the CASP3, CASP9, BCL-2 and NKX3-1 genes as candidate markers for prostate cancer susceptibility and poor prognosis.
Milene Roldão de SouzaMarilesia Ferreira de SouzaMonyse de NóbregaHeloísa Lizotti CiliãoMariana Bisarro Dos ReisPaulo Emilio FugantiIlce Mara de Syllos CólusPublished in: Molecular biology reports (2022)
Genetic polymorphisms in CASP3, NKX3-1, and BCL-2 genes were associated with susceptibility to PCa. The SNPs in the three genes alone and the SNP in the BCL-2 gene combined with the other two genes were strongly associated with adverse outcomes in PCa patients and are promising candidates for molecular markers for PCa prognosis.
Keyphrases
- genome wide
- poor prognosis
- genome wide identification
- prostate cancer
- copy number
- dna methylation
- bioinformatics analysis
- long non coding rna
- end stage renal disease
- ejection fraction
- genome wide analysis
- chronic kidney disease
- newly diagnosed
- transcription factor
- prognostic factors
- gene expression
- patient reported outcomes
- peritoneal dialysis