Deep learning offers promise in enhancing low-quality images by addressing weak fluorescence signals, especially in deep in vivo mouse brain imaging. However, current methods struggle with photon scarcity and noise within in vivo deep mouse brains, and often neglecting tissue preservation. In this study, we propose an innovative in vivo cortical fluorescence image restoration approach, combining signal enhancement, denoising, and inpainting. We curated a deep brain cortical image dataset and developed a novel deep brain coordinate attention restoration network (DeepCAR), integrating coordinate attention with optimized residual networks. Our method swiftly and accurately restores deep cortex images exceeding 800 μm, preserving small-scale tissue structures. It boosts the peak signal-to-noise ratio (PSNR) by 6.94 dB for weak signals and 11.22 dB for large noisy images. Crucially, we validate the effectiveness on external datasets with diverse noise distributions, structural features compared to those in our training data, showcasing real-time high-performance image restoration capabilities.
Keyphrases
- deep learning
- convolutional neural network
- artificial intelligence
- high resolution
- working memory
- resting state
- machine learning
- big data
- air pollution
- white matter
- functional connectivity
- systematic review
- cerebral ischemia
- randomized controlled trial
- optical coherence tomography
- blood brain barrier
- energy transfer
- mass spectrometry
- quality improvement
- photodynamic therapy