REST Regulates Non-Cell-Autonomous Neuronal Differentiation and Maturation of Neural Progenitor Cells via Secretogranin II.
Hyung Joon KimAhmet M DenliRebecca WrightTithi D BaulGregory D ClemensonAri S MorcosChunmei ZhaoSimon T SchaferFred H GageMohamedi N KagalwalaPublished in: The Journal of neuroscience : the official journal of the Society for Neuroscience (2016)
Our results reveal that REST regulates differentiation and maturation of neural progenitor cells in vitro by orchestrating both cell-intrinsic and non-cell-autonomous factors and that Scg2 is a major secretory target of REST with a differentiation-enhancing activity in a paracrine manner. In vivo, REST depletion causes accelerated differentiation of newborn neurons at the expense of spine defects, suggesting a potential role for REST in the timing of the maturation of granule neurons.