Reducing Capillary Leak Syndrome Mortality in Extremely Premature Infants: A Pilot Investigation.
Timothy J BolyMichell M Lozano-ChingaMelanie E Reyes-HernandezTimothy G ElginZuhair BallasJennifer R BermickPublished in: Clinical pediatrics (2024)
Neonatal capillary leak syndrome (CLS) is a rare, but life-threatening condition following neonatal sepsis or inflammatory injury. The objective of this study was to describe a standardized treatment approach for CLS that improves mortality and neonatal outcomes. A retrospective cohort study of 10 infants born at 22 to 26 weeks of gestation who developed CLS following a significant inflammatory insult was performed. Time to diagnosis and treatment approaches over 2 epochs were recorded and described. In epoch 2, with increased clinical awareness of CLS and implementation of a standardized treatment approach, there was a non-statistically significant decrease in the time to treatment with a significant decrease in mortality. An early targeted treatment approach for neonatal CLS can decrease mortality rates in this highly morbid condition.
Keyphrases
- cardiovascular events
- healthcare
- randomized controlled trial
- cardiovascular disease
- preterm infants
- intensive care unit
- bariatric surgery
- acute kidney injury
- type diabetes
- coronary artery disease
- metabolic syndrome
- drug delivery
- insulin resistance
- low birth weight
- adipose tissue
- preterm birth
- weight loss
- obese patients