SPSB1-mediated inhibition of TGF-β receptor-II impairs myogenesis in inflammation.

Yi LiNiklas DörmannBjörn BrinschwitzMelanie KnyElisa MartinKirsten BartelsNing LiPriyanka Voori GiriStefan SchwanzMichael BoschmannSusanne HilleBritta FielitzTobias WollersheimJulius GrunowStephan B FelixSteffen Weber-CarstensFriedrich C LuftOliver J MüllerJens Fielitz

Published in: Journal of cachexia, sarcopenia and muscle (2023)

Inflammatory cytokines via their respective signalling pathways cause an increase in SPSB1 expression in myocytes and attenuate myogenic differentiation. SPSB1-mediated inhibition of TβRII-Akt-Myogenin signalling and protein synthesis contributes to a disturbed myocyte homeostasis and myogenic differentiation that occurs during inflammation.

Keyphrases

oxidative stress
skeletal muscle
poor prognosis
signaling pathway
cell proliferation
binding protein
transforming growth factor
epithelial mesenchymal transition