The Prognostic Value of MRI Subventricular Zone Involvement and Tumor Genetics in Lower Grade Gliomas.

Gloria C ChiangDavid J PisapiaBenjamin LiechtyRajiv MaggeRohan RamakrishnaJonathan KniselyTheodore H SchwartzHoward A FineIlhami Kovanlikaya

Published in: Journal of neuroimaging : official journal of the American Society of Neuroimaging (2020)

Unlike in GBM, overall SVZ involvement was not found to strongly predict poor prognosis in LGGs. However, occipital SVZ involvement, though uncommon, was prognostic and found to be associated with CDKN2A/B mutations and tumor hypercellularity. Further investigation into these molecular mechanisms underlying occipital SVZ involvement in larger cohorts is warranted.

Keyphrases

poor prognosis
long non coding rna
magnetic resonance imaging
high grade
computed tomography
single molecule