A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos.
Chengchen ZhaoNaiqian ZhangYalin ZhangNuermaimaiti TuersunjiangShaorong GaoWenqiang LiuYong ZhangPublished in: Genome biology (2020)
Our study reveals the programmed DNA methylation heterogeneity during human pre-implantation embryogenesis through a novel mathematical model and provides valuable clues for identifying the driving factors of the first cell fate determination during this process.