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A DNA methylation state transition model reveals the programmed epigenetic heterogeneity in human pre-implantation embryos.

Chengchen ZhaoNaiqian ZhangYalin ZhangNuermaimaiti TuersunjiangShaorong GaoWenqiang LiuYong Zhang
Published in: Genome biology (2020)
Our study reveals the programmed DNA methylation heterogeneity during human pre-implantation embryogenesis through a novel mathematical model and provides valuable clues for identifying the driving factors of the first cell fate determination during this process.
Keyphrases
  • dna methylation
  • endothelial cells
  • gene expression
  • cell fate
  • genome wide
  • single cell
  • induced pluripotent stem cells
  • pluripotent stem cells
  • high resolution