Further Understanding of Urokinase Plasminogen Activator Overexpression in Urothelial Bladder Cancer Progression, Clinical Outcomes and Potential Therapeutic Targets.
Nico Christian GrossmannVictor Maximilian SchuettfortBenjamin PradereMarco MoschiniFahad QuhalHadi MostafaiShahrokh F ShariatSatoshi KatayamaEkaterina LaukhtinaKeiichiro MoriReza Sari MotlaghCédric PoyetMohammad AbufarajPierre I KarakiewiczShahrokh F ShariatDavid d'AndreaPublished in: OncoTargets and therapy (2021)
The overexpression of PAS components in UBC tumor tissue is associated with adverse pathological features and worse oncological outcomes. These findings are mainly based on preclinical studies and retrospective series, which requires further prospective studies to translate the PAS into clinically useful biomarkers and therapeutic targets.