Evaluation of changing the pattern of CTRP5 and inflammatory markers levels in patients with coronary artery disease and type 2 diabetes mellitus.
Nariman MoradiReza FadaeiElaheh RashidbeygiFatemeh Bagheri KargashehMojtaba MalekAbolfazl Shokoohi NahrkhalajiSoudabeh FallahPublished in: Archives of physiology and biochemistry (2020)
Purpose: It has recently found that adipokines, play a numerous functional roles in inflammation, lipids and glucose metabolism and in the pathogenically conditions such as atherosclerosis and insulin resistance. Therefore, for the first time we aimed the present study to evaluating serum levels of CTRP5 and inflammatory cytokines patients with CAD and T2DM in comparison with controls.Methods: This study was done on 44 patients with CAD, 45 type 2 diabetes mellitus (T2DM), 41 CAD + T2DM and 41 controls. Serum levels of TNF-α, IL-6, MCP-1 and CTRP5 were investigated by ELISA method.Results: The CTRP5 levels of all patients groups were lower in comparison with control group. There was a significant negative relationship between CTRP5 levels and cytokines concentration in the studied patients.Conclusions: Our findings suggested a potential role of CTRP5 in inflammatory process of underlying atherosclerosis and diabetes; however, more studies are needed to support these finding.
Keyphrases
- end stage renal disease
- glycemic control
- insulin resistance
- cardiovascular disease
- type diabetes
- newly diagnosed
- chronic kidney disease
- ejection fraction
- oxidative stress
- peritoneal dialysis
- prognostic factors
- rheumatoid arthritis
- metabolic syndrome
- adipose tissue
- patient reported outcomes
- mass spectrometry
- high fat diet
- skeletal muscle
- weight loss
- human health
- fatty acid