Oncotherapeutic Strategies in Early Onset Colorectal Cancer.
Mary O'ReillyAnna LinehanAleksandar KrsticWalter KolchKieran SheahanDes C WinterRay Mc DermottPublished in: Cancers (2023)
Early onset colorectal cancer (EOCRC), defined as colorectal cancers in patients aged less than 50 years, is becoming an increasingly common issue, globally. Since 1994, the incidence of this condition has been rising by 2% annually. Approximately one in five patients under 50 years of age diagnosed with colorectal cancer have an underlying genetic predisposition syndrome. The detection of cancer among the other 80% of patients poses a considerable task, as there is no family history to advocate for commencing early screening in this group. Patients with EOCRC have distinct social, spiritual, fertility, and financial needs from their older counterparts that need to be addressed. This review discusses the risk factors associated with the development of EOCRC and current best practice for the management of this disease.
Keyphrases
- early onset
- end stage renal disease
- ejection fraction
- chronic kidney disease
- healthcare
- primary care
- late onset
- peritoneal dialysis
- gene expression
- physical activity
- patient reported outcomes
- dna methylation
- risk factors
- quality improvement
- young adults
- patient reported
- health insurance
- quantum dots
- label free
- loop mediated isothermal amplification