Cell transcriptomic atlas of the non-human primate Macaca fascicularis.
Lei HanXiaoyu WeiChuanyu LiuGiacomo VolpeZhenkun ZhuangXuanxuan ZouZhifeng WangTaotao PanYue YuanXiao ZhangPeng FanPengcheng GuoYiwei LaiYing LeiXingyuan LiuFeng YuShuncheng ShangguanGuangyao LaiQiuting DengYa LiuLiang WuQuan ShiHao YuYunting HuangMengnan ChengJiangshan XuYang LiuMingyue WangChunqing WangYuanhang ZhangDuo XieYunzhi YangYeya YuHuiwen ZhengYanrong WeiFubaoqian HuangJunjie LeiWaidong HuangZhiyong ZhuHaorong LuBo WangXiaofeng WeiFengzhen ChenTao YangWensi DuJing ChenShi-Bo XuJuan AnCarl WardZongren WangZhong PeiChi-Wai WongXiaolei LiuHuafeng ZhangMingyuan LiuBaoming QinAxel SchambachJoan IsernLiqiang FengYan LiuXiangyu GuoZhen LiuQiang SunPatrick H MaxwellNick BarkerPura Muñoz-CánovesYing GuJan MulderMathias UhlenTao TanShi-Ping LiuHuanming YangJian WangYong HouXue LiuMiguel Angel EstebanLongqi LiuPublished in: Nature (2022)
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.