Immune cell C/EBPβ deficiency is associated with hepatic mononuclear defects and spontaneous hepatitis but not steatohepatitis induced liver fibrosis.

Itay MoshkovitsAyelet KaminitzDebby ReuveniMetsada Pasmanik-ChorEli BrazowskiAlexander MildnerAchim LeutzEhud Zigmond

Published in: Immunity, inflammation and disease (2022)

Immune-restricted C/EBPβ deficiency leads to significant alteration in hepatic mononuclear phagocytes composition associated with spontaneous mild hepatitis. Steatohepatitis associated fibrosis is not dependent on C/EBPβ expression by immune cells.

Keyphrases

liver fibrosis
peripheral blood
poor prognosis
high glucose
replacement therapy
binding protein
drug induced
oxidative stress
endothelial cells