Transient heart rate reduction improves acute decompensated heart failure-induced left ventricular and coronary dysfunction.
Nicolas PeschanskiNajah HaroukiMatthieu SoulieMarianne LachauxLionel NicolIsabelle Remy-JouetJean-Paul HenryAnais DumesnilSylvanie RenetFrançoise FougerousseEbba BrakenhielmAntoine Ouvrard-PascaudChristian ThuillezVincent RichardJérôme RousselPaul MulderPublished in: ESC heart failure (2021)
In a model mimicking human ADHF, early, but not delayed, transient HRR induced by the If current inhibitor S38844 opposes acute decompensation by preventing the decompensated-related aggravation of cardiovascular dysfunction as well as the development of pulmonary congestion, and these protective effects persist beyond the transient treatment. Whether early transient HRR induced by If current inhibitors or other bradycardic agents, i.e. beta-blockers, exerts beneficial effects in human ADHF warrants further investigation.
Keyphrases
- heart failure
- liver failure
- heart rate
- endothelial cells
- left ventricular
- cerebral ischemia
- drug induced
- heart rate variability
- high glucose
- blood pressure
- oxidative stress
- respiratory failure
- induced pluripotent stem cells
- coronary artery disease
- hepatitis b virus
- coronary artery
- pluripotent stem cells
- diabetic rats
- acute myocardial infarction
- aortic dissection
- brain injury
- ejection fraction
- intensive care unit
- aortic valve
- angiotensin converting enzyme
- mitral valve