Multiomic mapping of acquired chromosome 1 copy number and structural variants to identify therapeutic vulnerabilities in multiple myeloma.
Eileen Mary BoylePatrick BlaneyJames H StoeckleYubao WangHussein GhamlouchDylan GaglerMarc J BraunsteinLouis WilliamsAvital TenenbaumAriel M SiegelXiaoyi ChenGaurav VarmaJason AviganAlexander LiMonica JinsiDavid KaminetzkyArnaldo ArbiniLydia MontesJill CorreEven Holth RustadCarl Ola LandgrenFrancesco MauraBrian A WalkerMichael A BauerBenedetto BrunoAristotelis TsirigosFaith E DaviesGareth J MorganPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Multiple layers of genetic complexity impact the phenotype associated with CNAs on chr1 to generate its associated clinical phenotype. Whole-arm gains of 1q are the critically important prognostic group that deregulate multiple pathways, which may offer therapeutic vulnerabilities.