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Can harmonisation of outcomes bridge the translation gap for pre-clinical research? A systematic review of outcomes measured in mouse models of type 2 diabetes.

Nicola L HarmanAdrián Sanz-MorenoStamatia PapoutsopoulouKatie A LloydKamar E Ameen-AliMalcolm Robert MacLeodPaula R Williamson
Published in: Journal of translational medicine (2020)
There is heterogeneity of outcomes reported in pre-clinical research. Harmonisation of outcomes across the research pathway using a core outcome set may facilitate interpretation, evidence synthesis and translational success, and may contribute to the refinement of the use of animals in research. Systematic review registration: The study was prospectively registered on the PROSPERO Database, registration number CRD42018106831.
Keyphrases
  • systematic review
  • mouse model
  • emergency department
  • randomized controlled trial
  • insulin resistance
  • adverse drug