DNA methylation of tumour necrosis factor (TNF) alpha gene is associated with specific blood fatty acid levels in a gender-specific manner.

Bethan Hussey Richard P SteelBoakye GyimahJames C Reynolds Ian M Taylor Martin R Lindley Sarabjit Singh Mastana

Published in: Molecular genetics & genomic medicine (2021)

These results suggest that one way that fatty acids interact with the inflammation is through altered methylation profiles of cytokine genes; thus, providing potential therapeutic targets for nutritional and health interventions.

Keyphrases

fatty acid
genome wide
dna methylation
mental health
copy number
public health
genome wide identification
healthcare
oxidative stress
rheumatoid arthritis
gene expression
physical activity
genome wide analysis
bioinformatics analysis