Cisplatin-based chemoradiotherapy vs. cetuximab-based bioradiotherapy for p16-positive oropharyngeal cancer: an updated meta-analysis including trials RTOG 1016 and De-ESCALaTE.

Petar SutonMarko SkelinZoran RakusicStjepan DokuzovicIvica Luksic

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2019)

For patients with HPV-positive OPC, radiotherapy plus C225 showed inferior OS and higher LRR rates compared with radiotherapy plus CDDP. CDDP-based chemoradiotherapy should remain standard of definitive treatment of p16-positive OPC.

Keyphrases

locally advanced
rectal cancer
squamous cell carcinoma
radiation therapy
systematic review
early stage
papillary thyroid
radiation induced
randomized controlled trial
case control
young adults
metastatic colorectal cancer
smoking cessation