Body surface area-based vs concentration-based perioperative intraperitoneal chemotherapy after optimal cytoreductive surgery in colorectal peritoneal surface malignancy treatment: COBOX trial.
Lieselotte LemoineElsy ThijssenRobert CarleerKarlien GeboersPaul H SugarbakerKurt van der SpeetenPublished in: Journal of surgical oncology (2019)
Concentration-based chemotherapy delivers the drug in the most standardized way to the tumor nodule, resulting in increasing drug concentrations in the tumor nodule without increasing major morbidity.
Keyphrases
- locally advanced
- minimally invasive
- clinical trial
- study protocol
- coronary artery bypass
- patients undergoing
- cardiac surgery
- randomized controlled trial
- emergency department
- phase iii
- squamous cell carcinoma
- phase ii
- coronary artery disease
- rectal cancer
- combination therapy
- open label
- smoking cessation
- placebo controlled