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Zinc Finger MYND-Type Containing 8 (ZMYND8) is epigenetically regulated in mutant Isocitrate Dehydrogenase 1 (IDH1) glioma to promote radioresistance.

Stephen V CarneyKaushik BanerjeeAnzar A MujeebBrandon ZhuSantiago HaaseMaría Luisa VarelaPadma KadiyalaClaire E TronrudZiwen ZhuDevarshi MukherjiPreethi GorlaYilun SunRebecca TagettFelipe J NúñezMaowu LuoMaowu LuoMats LjungmanYayuan LiuZiyun XiaAnna A SchwendemanTingting QinMaureen A SartorJoseph F CostelloDaniel P CahillPedro R LowensteinMaria Graciela Castro
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
These findings indicate the impact of ZMYND8 in the maintenance of genomic integrity and repair of IR-induced DNA damage in mIDH1 glioma.
Keyphrases
  • dna damage
  • wild type
  • oxidative stress
  • diabetic rats
  • high glucose
  • dna repair
  • transcription factor
  • low grade
  • copy number
  • drug induced
  • dna damage response
  • gene expression
  • endothelial cells
  • high grade