The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells.

Xiao-Fan HuXiao-Tao HeKai-Xiang ZhouChen ZhangWen-Jun ZhaoTing ZhangJin-Lian LiJian-Ping DengYu-Lin Dong

Published in: Journal of neuroinflammation (2017)

Our results suggest that the upregulation of HDACs contributes to the pathological activation of spinal glial cells and the chronic pain caused by bone cancer, while T10 help to relieve BCP possibly via inhibiting the upregulation of HDACs in the glial cells in the SDH and then blocking the neuroinflammation induced by glial activation.

Keyphrases

induced apoptosis
chronic pain
neuropathic pain
signaling pathway
cell cycle arrest
spinal cord
cell proliferation
poor prognosis
spinal cord injury
endoplasmic reticulum stress
squamous cell carcinoma
pain management
squamous cell
body composition
young adults
brain injury
inflammatory response
anti inflammatory