Increased expression profile of NCSTN, Notch and PI3K/AKT3 in hidradenitis suppurativa.
Schapoor HessamThilo GambichlerM SkryganL SchollM SandThomas MeyerE StockflethF G BecharaPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)
We found no evidence for diminished expression levels of the Notch signalling. In contrast, the NCSTN, Notch and PI3K/AKT signalling components are overexpressed in HS. Future research is needed to investigate a possible pathogenetic role or to reveal a coactivation of these overexpressed components during inflammatory response in HS.