Anti-CTLA-4 Antibody Might Be Effective Against Non-small Cell Lung Cancer With Large Size Tumor.

Hiroshi SaijoYoshihiko HirohashiOsamu HonjoToyohiro SaikaiNaoki ShijuboHirotsugu TakabatakeAkihisa FujitaYasuhito HondaHiroyuki KobaHirofumi ChibaToshihiko Torigoe

Published in: Anticancer research (2023)

Anti-PD-1 antibody monotherapy might be less effective against large NSCLC due to the infiltration of Treg cells. Therefore, it might be appropriate for large NSCLC to select a treatment including an anti-CTLA-4 antibody, which can target Treg cells.

Keyphrases

induced apoptosis
small cell lung cancer
cell cycle arrest
advanced non small cell lung cancer
endoplasmic reticulum stress
combination therapy
randomized controlled trial
clinical trial