Dietary Lactobacillus-Derived Exopolysaccharide Enhances Immune-Checkpoint Blockade Therapy.

Hirotaka Kawanabe-Matsuda Kazuyoshi TakedaMarie NakamuraSeiya MakinoTakahiro Karasaki Kazuhiko Kakimi Megumi Nishimukai Tatsukuni OhnoJumpei OmiKuniyuki Kano Akiharu UwamizuHideo YagitaIvo Gomperts BonecaGérard EberlJunken AokiMark J SmythKo Okumura

Published in: Cancer discovery (2022)

Gut microbiota- and probiotic-derived metabolites are attractive agents to augment the efficacy of immunotherapies. Here we demonstrated that dietary consumption of Lactobacillus-derived exopolysaccharide induced CCR6+ CD8+ T cells in Peyer's patches and improved the tumor microenvironment to augment the therapeutic effects of immune-checkpoint blockade against CCL20-producing tumors. See related commentary by Di Luccia and Colonna, p. 1189. This article is highlighted in the In This Issue feature, p. 1171.

Keyphrases

machine learning
ms ms
lactic acid
deep learning
diabetic rats
dendritic cells
high glucose
stem cells
immune response
endothelial cells
cell therapy