Long Non-Coding RNA (lncRNA) Roles in Cell Biology, Neurodevelopment and Neurological Disorders.
Vincenza AlipertiJustyna SkoniecznaAndrea CerasePublished in: Non-coding RNA (2021)
Development is a complex process regulated both by genetic and epigenetic and environmental clues. Recently, long non-coding RNAs (lncRNAs) have emerged as key regulators of gene expression in several tissues including the brain. Altered expression of lncRNAs has been linked to several neurodegenerative, neurodevelopmental and mental disorders. The identification and characterization of lncRNAs that are deregulated or mutated in neurodevelopmental and mental health diseases are fundamental to understanding the complex transcriptional processes in brain function. Crucially, lncRNAs can be exploited as a novel target for treating neurological disorders. In our review, we first summarize the recent advances in our understanding of lncRNA functions in the context of cell biology and then discussing their association with selected neuronal development and neurological disorders.
Keyphrases
- long non coding rna
- poor prognosis
- gene expression
- cerebral ischemia
- mental health
- single cell
- network analysis
- dna methylation
- transcription factor
- genome wide identification
- cell therapy
- white matter
- resting state
- subarachnoid hemorrhage
- genome wide
- brain injury
- stem cells
- functional connectivity
- bone marrow
- long noncoding rna
- mental illness
- mesenchymal stem cells
- risk assessment
- heat shock