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Diuretic Changes, Health Care Resource Utilization, and Clinical Outcomes for Heart Failure With Reduced Ejection Fraction: From the Change the Management of Patients With Heart Failure Registry.

Muhammad Shahzeb KhanStephen J GreeneAnne S HellkampAdam D DeVoreXian ShenNancy M AlbertJ Herbert PattersonJohn A SpertusLaine E ThomasFredonia B WilliamsAdrian F HernandezGregory Y H LipJaved Butler
Published in: Circulation. Heart failure (2021)
In this contemporary US registry, 1 in 4 patients with heart failure with reduced ejection fraction had outpatient escalation of diuretic therapy over longitudinal follow-up, and these patients were more likely to have sign/symptoms of congestion. Outpatient diuretic dose escalation of any magnitude was associated with heart failure hospitalizations and resource utilization, but not all-cause mortality.
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