Diuretic Changes, Health Care Resource Utilization, and Clinical Outcomes for Heart Failure With Reduced Ejection Fraction: From the Change the Management of Patients With Heart Failure Registry.
Muhammad Shahzeb KhanStephen J GreeneAnne S HellkampAdam D DeVoreXian ShenNancy M AlbertJ Herbert PattersonJohn A SpertusLaine E ThomasFredonia B WilliamsAdrian F HernandezGregory Y H LipJaved ButlerPublished in: Circulation. Heart failure (2021)
In this contemporary US registry, 1 in 4 patients with heart failure with reduced ejection fraction had outpatient escalation of diuretic therapy over longitudinal follow-up, and these patients were more likely to have sign/symptoms of congestion. Outpatient diuretic dose escalation of any magnitude was associated with heart failure hospitalizations and resource utilization, but not all-cause mortality.
Keyphrases
- heart failure
- acute heart failure
- healthcare
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- open label
- prognostic factors
- left ventricular
- atrial fibrillation
- cardiac resynchronization therapy
- stem cells
- randomized controlled trial
- patient reported outcomes
- bone marrow
- health information
- cell therapy