The cytokine receptor Fn14 is a molecular brake on neuronal activity that mediates circadian function in vivo .

expression in pyramidal neurons of the hippocampus Fn14 constrains neuronal activity near daily transitions between light and darkLoss of Fn14 lengthens the endogenous circadian period and disrupts sleep-wake states and memoryMicroglia contact excitatory synapses in an Fn14-dependent manner.