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Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca 2+ sensitivity but has limited effect on systemic metabolism.

Kerry McLaughlinSamuel AcremanSameena NawazJoseph CutteridgeAnne ClarkJakob G KnudsenGeoffrey DenwoodAliya F SpigelmanJocelyn E Manning FoxSumeet Pal SinghPatrick E MacDonaldBenoit HastoyQuan Zhang
Published in: Diabetic medicine : a journal of the British Diabetic Association (2022)
-dependent exocytosis in β-cells. Its function is more significant in human β-cells than their rodent counterparts.
Keyphrases
  • induced apoptosis
  • poor prognosis
  • cell cycle arrest
  • cell therapy
  • endoplasmic reticulum stress
  • cell death
  • stem cells
  • signaling pathway
  • protein kinase
  • bone marrow
  • cell proliferation
  • pi k akt
  • drug induced