PET imaging of PARP expression using 68 Ga-labelled inhibitors.

Xiangwei WangWei LiuKe LiKaiwen ChenSimin HeJianping ZhangBingxin GuXiaoping XuShaoli Song

Published in: European journal of nuclear medicine and molecular imaging (2023)

Ga-DOTA-Olaparib displayed high stability and quick PARP imaging in a tumor model. This compound is thus a promising imaging agent that can be used in a personalized PARP inhibitor treatment regimen.

Keyphrases

pet imaging
pet ct
dna damage
dna repair
high resolution
positron emission tomography
poor prognosis
mass spectrometry
binding protein
combination therapy