Genetically Predicted Blood Pressure and Cognition in Midlife: A UK Biobank Study.

Matthew Joseph LennonAnbupalam ThalamuthuBen Chun Pan Lam John D Crawford Perminder Singh Sachdev

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

Genetic propensity for high and low BP impacts on midlife cognition in subtle ways and differentially affects cognitive domains. While a genetic propensity to low BP may preserve nontimed tests in midlife, it may come at a trade-off with worsened attention scores and RT.

Keyphrases

blood pressure
genome wide
mild cognitive impairment
white matter
copy number
working memory
heart rate
hypertensive patients
gene expression
metabolic syndrome
dna methylation
cross sectional
skeletal muscle