Assessment of the influence of Fc gamma receptors polymorphisms on biologics' pharmacokinetics in Tunisian rheumatoid arthritis patients.

Mahmoud InesMyriam MoallaBen Tekaya AichaCharfi RimRouached LeilaBouden SelmaTekaya RawdhaSaidane OlfaAbdelmoula LeilaSfar Imen

Published in: British journal of clinical pharmacology (2023)

Our work supports the hypothesis of an impact of FCGR SNPs on biologics' immunogenicity, particularly FCGR R131H polymorphism, but further studies with larger cohorts needs to be undertaken to confirm these results.

Keyphrases

rheumatoid arthritis patients
disease activity
genome wide
rheumatoid arthritis
systemic lupus erythematosus
case control
gene expression
dna methylation