The present published evidence suggests that WJ tissue and associated MSCs offer an encouraging alternative for the management of knee OA. The published in vitro, preclinical and clinical investigations demonstrate the therapeutic potential of WJ and promote further research in this field to provide symptomatic relief to patients suffering from OA, aiming also to regenerate the osteoarthritic hyaline cartilage, with disease-modifying effects. Future adequately powered randomized controlled trials should be undertaken to establish whether WJ is helpful in the management of OA of the knee.
Keyphrases
- knee osteoarthritis
- total knee arthroplasty
- end stage renal disease
- randomized controlled trial
- newly diagnosed
- ejection fraction
- chronic kidney disease
- anterior cruciate ligament
- anterior cruciate ligament reconstruction
- meta analyses
- peritoneal dialysis
- prognostic factors
- mesenchymal stem cells
- stem cells
- systematic review
- extracellular matrix