Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Kenichi OkudaGang ChenDurai B SubramaniMonroe WolfRodney C GilmoreTakafumi KatoGiorgia RadicioniMehmet KesimerMichael ChuaHong DangAlessandra Livraghi-ButricoCamille EhreClaire M DoerschukScott H RandellHirotoshi MatsuiTakahide NagaseWanda K O'NealRichard C Boucher

Published in: American journal of respiratory and critical care medicine (2020)

In normal/healthy human airways, MUC5B is the dominant secretory mucin in the superficial epithelium and glands, with distal airways being a major site of expression. MUC5B and MUC5AC expression is a property of CCSP-positive secretory cells in superficial airway epithelia.

Keyphrases

endothelial cells
cystic fibrosis
poor prognosis
induced pluripotent stem cells
induced apoptosis
cell proliferation
oxidative stress
cell death